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Bk-2C-B (also known as Bk-2C-B, or beta-keto 2C-B) is a novel synthetic psychedelic substance of the phenethylamine chemical class that produces psychedelic effects comparable to members of the 2C-x family when administered.

Compared to its structural analog 2C-B, its effects are often described as being considerably more stimulating and less psychedelic with a significantly longer duration.This compound is relatively uncommon and has little to no history of human use prior to its 2014 distribution by online vendors as a research chemical.]=+]=Very little data exists about the pharmacological properties, metabolism, and toxicity of BK-2C-B. As a result, users are advised to approach this novel and poorly understood hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

βk-2C-B, or beta-keto 2C-B, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. βk-2C-B contains the structure of 2C-B substituted with a ketone group at the beta carbon of the structure (R1). βk-2C-B contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring. βk-2C-B belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.
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Bk-2C-B likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from its efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

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