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MDPV (Methylenedioxypyrovalerone) is a stimulant drug of the cathinone class which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim.
It remained an obscure stimulant drug until around 2004 when it was reportedly sold as a designer drug. Until banned in 2011, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations and convenience stores in the United States, similar to the marketing for Spice and K2 as incense.

Substance Identification

Formal name is 1-(1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one.
The chemical formula for MDPV is C16H21NO3 with a molecular weight of 275.343

Effect and Dosage
MDPV acts as a stimulant drug and has been reported to produce effects similar to those of cocaine, methylphenidate, and amphetamines.
The primary psychological effects have a duration of roughly 3 to 4 hours, with aftereffects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours.
Also, there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. It has also been repeatedly noted to induce irresistible cravings to re-administer.

Toxicology

-The toxicity and long-term health impacts of recreational MDPV use don’t appear to have been studied in any scientific context and the specific harmful dose is obscure.
-Thе thеrареutіс іndеx mentioned for MDPV іn the оrіgіnаl patent literature wаѕ 875 bаѕеd оn ѕubсutаnеоuѕ (s.c.) administration in mice.

Appearance
The hydrochloride salt exists as a very fine crystalline powder that is hygroscopic. Thus, it tends to form clumps, resembling something like powdered sugar.

Also, its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors

Pharmacology

Methylenedioxypyrovalerone has a record of FDA-approved medical use. It has been shown to produce robust reinforcing effects and compulsive self-administration in rats,

though this had already been provisionally established by a number of documented cases of misuse and addiction in humans before the animal tests were carried out.

MDPV is the 3,4-methylenedioxy ring-substitutes analog of the compound pyrovalerone,

develope in the 1960s, which is use for the treatment of chronic fatigue and as an anorectic.

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